2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase

NO Synthase

Nitric oxide synthases; NOS

NO Synthase

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Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N15510
    Harzianol J
    		Inhibitor
    Harzianol J is a harziane - type diterpene compound discovered from the deep - sea - sediment fungus Trichoderma sp. SCSIOW21. Harzianol J has certain anti - inflammatory activity. At a concentration of 100 µM, its inhibition rate of NO is 81.8%, and its IC50 value for inhibiting the production of NO is 66.7 µM. Harzianol J can be used in the research of the anti - inflammatory field.
    Harzianol J
  • HY-N7878
    Tectorigenin sodium sulfonate
    		Inhibitor
    Tectorigenin sodium sulfonate is the product of tectorigenin sulfonated with sulfuric acid and mixed with saturated salt water. Tectorigenin sodium sulfonate has high water-solubility and good antioxidant properties.
    Tectorigenin sodium sulfonate
  • HY-W484263
    hnNOS-IN-3
    		Inhibitor
    hnNOS-IN-3 (compound 39) is a selective nNOS inhibitor, with a Ki of 0.32 μM. The nNOS binding of hnNOS-IN-3 is competitive with L-arginine. The selectivity of hnNOS-IN-3 for nNOS versus iNOS (Ki=37 μM) and eNOS (Ki=9.4 μM) is 115-fold and 29-fold, respectively.
    hnNOS-IN-3
  • HY-119873
    Celiprolol
    		Activator
    Celiprolol (REV 5320) is a potent, cardioselective and orally active β1-andrenoceptor r antagonist with partial β2 agonist activity, with Ki values of 0.14-8.3 μM. Celiprolol has antihypertensive and antianginal activity, and can be used for the research of cardiovascular disease such as high blood pressure.
    Celiprolol
  • HY-N15502
    Cycloneroside A
    		Inhibitor
    Cycloneroside A is a sesquiterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Cycloneroside A has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is approximately 100 µM. Cycloneroside A can be used in the research of the anti-inflammatory field.
    Cycloneroside A
  • HY-P10384A
    SPSB2-iNOS inhibitory cyclic peptide-2 TFA
    SPSB2-iNOS inhibitory cyclic peptide-2 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-2 (HY-P10384). SPSB2-iNOS inhibitory cyclic peptide-2 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 21 nM. SPSB2-iNOS inhibitory cyclic peptide-2 TFA is reduction-resistant and oxidatively stable.
    SPSB2-iNOS inhibitory cyclic peptide-2 TFA
  • HY-N9297
    Oxyphyllenone A
    		Inhibitor
    Oxyphyllenone A is an inhibitor of NO Synthase. Oxyphyllenone A inhibits the NO production in lipopolysaccharide-activated macrophages with an IC50 of 28 μM.
    Oxyphyllenone A
  • HY-P10385A
    SPSB2-iNOS inhibitory cyclic peptide-3 TFA
    SPSB2-iNOS inhibitory cyclic peptide-3 TFA is the TFA salt form of SPSB2-iNOS inhibitory cyclic peptide-3 (HY-P10385). SPSB2-iNOS inhibitory cyclic peptide-3 TFA is an inhibitor for the interaction of SPRY domain and SOCS-box protein 2 (SPSB2) and iNOS, through binding SPSB2 on iNOS site with KD of 7 nM.
    SPSB2-iNOS inhibitory cyclic peptide-3 TFA
  • HY-N0041R
    Ginsenoside Rb3 (Standard)
    		Inhibitor
    Ginsenoside Rb3 (Standard) is the analytical standard of Ginsenoside Rb3. This product is intended for research and analytical applications. Ginsenoside Rb3 is extracted from steamed Panax ginseng C. A. Meyer. Ginsenoside Rb3 exhibits inhibitory effect on TNFα-induced NF-κB transcriptional activity with an IC50 of 8.2 μM in 293T cell lines. Ginsenoside Rb3 also inhibits the induction of COX-2 and iNOS mRNA.
    Ginsenoside Rb3 (Standard)
  • HY-69019A
    7-Nitroindazole sodium
    		Inhibitor
    7-Nitroindazole sodium is a selective and BBB-penetrable inhibitor of nitric oxide synthase (NOS). 7-Nitroindazole sodium can inhibit the activity of central NOS with an IC50 of 0.47 μM in the cerebellum of mice. 7-Nitroindazole sodium has anti-injurious and neuroprotective properties.
    7-Nitroindazole sodium
  • HY-N0006R
    Demethoxycurcumin (Standard)
    Demethoxycurcumin (Standard) is the analytical standard of Demethoxycurcumin. This product is intended for research and analytical applications. Demethoxycurcumin is one of the main active ingredients of curcumin, which has anti-inflammatory, antioxidant, antibacterial, anti-cancer and neuroprotective effects. Demethoxycurcumin is orally active. Demethoxycurcumin can be used in inflammation, cancer and Alzheimer's disease research.
    Demethoxycurcumin (Standard)
  • HY-N0904R
    Ginsenoside C-K (Standard)
    		Inhibitor
    Ginsenoside C-K (Standard) is the analytical standard of Ginsenoside C-K. This product is intended for research and analytical applications. Ginsenoside C-K, a bacterial metabolite of G-Rb1, exhibits anti-inflammatory effects by reducing iNOS and COX-2. Ginsenoside C-K exhibits an inhibition against the activity of CYP2C9 and CYP2A6 in human liver microsomes with IC50s of 32.0±3.6 μM and 63.6±4.2 μM, respectively.
    Ginsenoside C-K (Standard)
  • HY-N8428
    Canophyllal
    		Inhibitor
    Canophyllal is a triterpene that can be isolated from the leaves of Elsholtzia ciliata. Canophyllal weakly inhibits the production of NO.
    Canophyllal
  • HY-N11548
    Inflexuside A
    		Inhibitor
    Inflexuside A, an abietane diterpenoid, can be isolated from the aerial parts of Isodon inflexus. Inflexuside B strongly inhibits lipopolysaccharide (LPS)-activated NO production (NO Synthase) in RAW264.7 macrophages.
    Inflexuside A
  • HY-N1382R
    Asperuloside (Standard)
    		Inhibitor
    Asperuloside (Standard) is the analytical standard of Asperuloside. This product is intended for research and analytical applications. Asperuloside is an iridoid isolated from Hedyotis diffusa, with anti-inflammatory activity. Asperuloside inhibits inducible nitric oxide synthase (iNOS), suppresses NF-κB and MAPK signaling pathways.
    Asperuloside (Standard)
  • HY-P10092
    SP6
    		Activator
    SP6 exertes an antihypertensive effect through vascular NO regulation.
    SP6
  • HY-172102
    NLRP3-IN-68
    		Inhibitor
    NLRP3-IN-68 (Compound 2d) is a 1,3,4-oxadiazole derivative. NLRP3-IN-68 has strong anti-inflammatory and antioxidant activities, which can inhibit inflammatory cytokines secretion, iNOS expression and NLRP3 inflammasome activation. NLRP3-IN-68 can be used in the research of anti-inflammatory drugs.
    NLRP3-IN-68
  • HY-W670564A
    (4S)-10-Nor-calamenen-10-one
    		Inhibitor
    (4S)-10-Nor-calamenen-10-one (Compound 15) enhances LPS-induced NO production by microglia. (4S)-10-Nor-calamenen-10-one is an eudesmane sesquiterpene that can be isolated from Alpinia oxyphylla.
    (4S)-10-Nor-calamenen-10-one
  • HY-13683S2
    Mifepristone-d6
    		Inhibitor
    Mifepristone-d6 is deuterated labeled Mifepristone (HY-13683). Mifepristone (RU486) is a progesterone receptor (PR) and glucocorticoid receptor (GR) antagonist with IC50s of 0.2 nM and 2.6 nM in in vitro assay.
    Mifepristone-d<sub>6</sub>
  • HY-NP203
    High density lipoprotein (human)
    		Activator
    High density lipoprotein (HDL) (human) is a functional lipoprotein that binds to receptors such as scavenger receptor B1 (SR-B1), ABCA1 and ABCG1. High density lipoprotein (human) clears excess cholesterol from peripheral tissues through reverse cholesterol transport (RCT) and transports it to the liver for metabolism, while activating endothelial nitric oxide synthase (eNOS) to produce nitric oxide (NO), exerting antioxidant, anti-inflammatory, and vascular endothelial protective activities. High density lipoprotein (human) is promising for research of cardiovascular diseases, such as atherosclerosis.
    High density lipoprotein (human)
Cat. No. Product Name / Synonyms Application Reactivity
NO Synthase Isoform Comparison

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