2. Signaling Pathways
  3. Immunology/Inflammation
  4. NO Synthase

NO Synthase

Nitric oxide synthases; NOS

NO Synthase

Related Products

PDF 1.66 MB

Nitric oxide synthases (NOSs) are a family of enzymes catalyzing the production of nitric oxide (NO) from L-arginine. NO synthases catalyze the oxidation of L-arginine to NO and L-citrulline. Mammals contain three NOS isoforms: neuronal NOS (nNOS), inducible NOS (iNOS), and endothelial NOS (eNOS). NO produced from these different NOS isoforms is involved in a wide range of physiologic functions in the nervous, immune, and cardiovascular systems. Unregulated NO production can lead to pathologic conditions such as stroke, inflammation, and hypertension. Therefore, the control of NOS activity by isoform selective NOS inhibitors has great potential for therapeutic treatments of NO-related diseases.

NO Synthase Isoform Specific Products:

NO Synthase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-13562
    Banoxantrone
    		Activator
    Banoxantrone (AQ4N), as a prototype hypoxia selective cytotoxin, can be reduced to AQ4, a potent topoisomerase II inhibitor. Banoxantrone selectively kills hypoxic cells via an iNOS-dependent mechanism. Banoxantrone shows a potent cytotoxicity and hypoxia-selective effect enhanced by radiation.
    Banoxantrone
  • HY-136341R
    7,8-Dihydroneopterin (Standard)
    		Activator
    Sanguinarine (Standard) is the analytical standard of Sanguinarine. This product is intended for research and analytical applications. Sanguinarine (Sanguinarin), a benzophenanthridine alkaloid derived from the root of Sanguinaria Canadensis, can stimulate apoptosis via activating the production of reactive oxygen species (ROS). Sanguinarine-induced apoptosis is associated with the activation of JNK and NF-κB.
    7,8-Dihydroneopterin (Standard)
  • HY-N15512
    Harzianol L
    		Inhibitor
    Harzianol L is found in Trichoderma sp. SCSIOW21. Harzianol L can inhibit the production of NO and exhibit anti-inflammatory activity.
    Harzianol L
  • HY-N15602
    Isosojagol
    		Inhibitor
    Isosojagol (Compound 5) is a α-Glucosidase inhibitor with an IC50 of 32.2  μM. Isosojagol can be isolated from the Roots of Dolichos trilobus. Isosojagol has anti-inflammatory activity and inhibits LPS (HY-D1056A1)-induced NO production in RAW264.7 cells. Isosojagol can be used for fracture, soft tissue injuries and rheumatoid arthritis research.
    Isosojagol
  • HY-139135
    Methyl-L-NIO hydrochloride
    		Inhibitor
    Methyl-L-NIO (compound 2d) hydrochloride is a potential selective inhibitor (IC50: 70 μM) of dimethylarginine dimethylaminohydrolase hDDAH. Methyl-L-NIO also has inhibitory activity against NO synthase. The inhibition rates of Methyl-L-NIO on different isoforms of NO synthase at a concentration of 100 μM are 77% (nNOS), 20% (eNOS), and 72% (iNOS) respectively; the inhibition rates at a concentration of 1 mM are 100% (nNOS), 85% (eNOS), 100% (iNOS).
    Methyl-L-NIO hydrochloride
  • HY-N15689
    Dichotomine E
    		Inhibitor
    Dichotomine E is a β-carboline alkaloid that can be isolated from the root of Stellaria dichotoma var. lanceolata. Dichotomine E has anti-inflammatory property for the inhibition of NO production in LPS (HY-D1056)-treated RAW264.7 cells.
    Dichotomine E
  • HY-N15509
    Harzianol K
    		Inhibitor
    Harzianol K is a novel harziane - type diterpene derivative discovered from the deep - sea sediment fungus Trichoderma sp. SCSIOW21. It has an inhibitory effect on NO production and can be used in the research of the anti - inflammatory field.
    Harzianol K
  • HY-N6770
    Curvularin
    		Inhibitor
    Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM.
    Curvularin
  • HY-N0948A
    (+)-Rhododendrol
    		Inhibitor
    (+)-Rhododendrol ((S)-(+)-Rhododendrol) is an anti-inflammatory agent that can suppress NO production.
    (+)-Rhododendrol
  • HY-174260
    Neuroprotective agent 11
    Neuroprotective agent 11 (Compound 1a) is an orally active polyphenol compound with significant protective effects against cerebral ischemia. The main activities of Neuroprotective agent 11 include inhibiting neuronal inflammation and apoptosis, reducing cerebral infarction volume, and improving behavioral symptoms of cerebral ischemic mice. Neuroprotective agent 11 exerts its regulatory mechanism by downregulating the expression of inflammatory factors (iNOS、COX-2) and apoptotic proteins (cleaved-Caspase3, p53). Neuroprotective agent 11 can be used in the study of cerebral ischemia-related diseases (such as ischemic stroke).
    Neuroprotective agent 11
  • HY-161255
    3,4-DAA
    		Inhibitor
    3,4-DAA is an orally active Anthranilic acid derivative with potent immunosuppressive activities. 3, 4-DAA can alleviate the severity of colitis through inhibiting Th1 cells response, promoting Th2 cytokines expression and inducing CD4+CD25+ T cells expression. 3,4-DAA suppressed expression of inducible nitric oxide synthase (iNOS) and nitric oxide (NO) release from EOC20 cells induced by IFN-γ and Lipopolysaccharide.
    3,4-DAA
  • HY-W746847
    Epibetulinic acid-d3
    Epibetulinic acid-d3 is the deuterium labeled Epibetulinic acid (HY-N0223). Epibetulinic acid exhibits potent inhibitory effects on NO and prostaglandin E2 (PGE2) production in mouse macrophages (RAW 264.7) stimulated with bacterial endotoxin with IC50s of 0.7 and 0.6 μM, respectively. Anti-inflammatory activity.
    Epibetulinic acid-d<sub>3</sub>
  • HY-143456
    Anti-inflammatory agent 18
    		Inhibitor
    Anti-inflammatory agent 18 (compound 3b) shows NO inhibitory activity, with an IC50 of 15.94 μM. Anti-inflammatory agent 18 inhibits HMGB1-induced later inflammation. Anti-inflammatory agent 18 can be used for the research of later inflammation diseases such as coronavirus diseases (COVID-19) and sepsis, etc.
    Anti-inflammatory agent 18
  • HY-P0184
    Camstatin
    		Inhibitor
    Camstatin, a functionally active 25-residue fragment of PEP-19's IQ motif, binds calmodulin and inhibits neuronal nitric oxide (NO) synthase.
    Camstatin
  • HY-12119B
    GW274150 dihydrochloride
    		Inhibitor
    GW274150 (dihydrochloride) is a potent, selective, orally active and NADPH-dependent inhibitor of human inducible nitric oxide synthase (iNOS) (IC50=2.19 μM; Kd=40 nM) and rat iNOS (ED50=1.15 μM). GW274150 (dihydrochloride) displays less potency for both humans or rats endothelial NOS (eNOS) and neuronal NOS (nNOS). GW274150 (dihydrochloride) exerts a protective role in an acute model of lung injury inflammation.
    GW274150 dihydrochloride
  • HY-N8819
    Methyl ganoderate H
    		Inhibitor
    Methyl ganoderate H is a natural product that can be isolated from Ganoderma lucidum. Methyl ganoderate H has moderate inhibitory effect to NO production.
    Methyl ganoderate H
  • HY-N7656
    5,7,8-Trimethoxyflavone
    5,7,8-Trimethoxyflavone (Norwogonin 5,7,8-trimethyl ether), isolated from Andrographis echioides, inhibits NO with an IC50 of 39.1 μM. 5,7,8-Trimethoxyflavone has anti-inflammatory activity.
    5,7,8-Trimethoxyflavone
  • HY-125458
    Iromycin A
    		Inhibitor
    Iromycin A is a potent inhibitor of nitric oxide synthases (NO synthase) that can be isolated from Streptomyces sp..
    Iromycin A
  • HY-145870
    Anti-inflammatory agent 13
    		Inhibitor
    Anti-inflammatory agent 13 (Compound 3) is a pentacyclic triterpene compound. Anti-inflammatory agent 13 exhibits a considerable inhibitory effect on inflammation models. Anti-inflammatory agent 13 has the potential for the research of either DAMPs or PAMPs triggered inflammation.
    Anti-inflammatory agent 13
  • HY-N15501
    Trichaspside F
    		Inhibitor
    Trichaspside F is a sesquiterpene aminoglycoside compound discovered from Trichoderma sp. SCSIOW21. Trichaspside F has the activity of inhibiting the production of NO. In the experiment with macrophage RAW 264.7 cells, its IC50 value for inhibiting the production of NO is 54.8 µM. Trichaspside F can be used in the research of the anti-inflammatory field.
    Trichaspside F
Cat. No. Product Name / Synonyms Application Reactivity
NO Synthase Isoform Comparison

Your Search Returned No Results.

Sorry. There is currently no product that acts on isoform together.

Please try each isoform separately.